No, your frozen breast milk pouches need be flat to freeze dry. Our insulated cooler size estimates are based on rectangular, flat, 5-6oz frozen pre-sterile milk pouches. Freezing flat may help in maximizing the space within our insulated cooler when shipping. If you have variable shapes and size pouches, we would recommend ordering the next size shipping box. If you need help in deterring which shipping kit you require, please call or text (602)456-1492 or email ilove@boobiejuice.com